Article
Influence of genetic variation of the β2-adrenergic receptor on lung diffusion in patients with cystic fibrosis.
Pulmonary pharmacology & therapeutics - 1 Oct 2011
Traylor Brittany R, Wheatley Courtney M, Skrentny Thomas T, Foxx-Lupo William T, Phan Hanna, Patanwala Asad E, Morgan Wayne J, Daines Cori L, Sprissler Ryan, Snyder Eric M
Abstract excerpt
RATIONALE: Cystic fibrosis (CF) is a disease that adversely affects the lung resulting in a reduction in lung diffusion. Stimulation of the β(2)-adrenergic receptors mediates mucociliary clearance and bronchodilation. We sought to determine the influence of an inhaled β-agonist on the diffusing capacity of the lungs for carbon monoxide (DLCO), alveolar-capillary membrane conductance (D(M)), pulmonary capillary...
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