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Article

Nuclear factor-κB-dependent epithelial to mesenchymal transition induced by HIF-1α activation in pancreatic cancer cells under hypoxic conditions.

PloS one - 1 Jan 2011

Cheng Zhuo-Xin, Sun Bei, Wang Shuang-Jia, Gao Yue, Zhang Ying-Mei, Zhou Hao-Xin, Jia Guang, Wang Yong-Wei, Kong Rui, Pan Shang-Ha, Xue Dong-Bo, Jiang Hong-Chi, Bai Xue-Wei

Abstract excerpt

BACKGROUND: Epithelial to mesenchymal transition (EMT) induced by hypoxia is one of the critical causes of treatment failure in different types of human cancers. NF-κB is closely involved in the progression of EMT. Compared with HIF-1α, the correlation between NF-κB and EMT during hypoxia has been less studied, and although the phenomenon was observed in the past, the molecular mechanisms involved remained...

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Identifiers

PMID: 21887310
DOI: 10.1371/journal.pone.0023752
PMCID: PMC3161785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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