Article
TASK-3 as a potential antidepressant target.
Brain research - 6 Oct 2011
Gotter Anthony L, Santarelli Vincent P, Doran Scott M, Tannenbaum Pamela L, Kraus Richard L, Rosahl Thomas W, Meziane Hamid, Montial Marina, Reiss Duane R, Wessner Keith, McCampbell Alexander, Stevens Joanne, Brunner Joseph I, Fox Steven V, Uebele Victor N, Bayliss Douglas A, Winrow Christopher J, Renger John J
Abstract excerpt
Modulation of TASK-3 (Kcnk9) potassium channels affect neurotransmitter release in thalamocortical centers and other sleep-related nuclei having the capacity to regulate arousal cycles and REM sleep changes associated with mood disorders and antidepressant action. Circumstantial evidence from this and previous studies suggest the potential for TASK-3 to be a novel antidepressant therapeutic target; TASK-3...
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