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Article

Monosomy of chromosome 10 associated with dysregulation of epidermal growth factor signaling in glioblastomas.

JAMA - 15 Jul 2009

Yadav Ajay K, Renfrow Jaclyn J, Scholtens Denise M, Xie Hehuang, Duran George E, Bredel Claudia, Vogel Hannes, Chandler James P, Chakravarti Arnab, Robe Pierre A, Das Sunit, Scheck Adrienne C, Kessler John A, Soares Marcelo B, Sikic Branimir I, Harsh Griffith R, Bredel Markus

Abstract excerpt

CONTEXT: Glioblastomas--uniformly fatal brain tumors--often have both monosomy of chromosome 10 and gains of the epidermal growth factor receptor (EGFR) gene locus on chromosome 7, an association for which the mechanism is poorly understood. OBJECTIVES: To assess whether coselection of EGFR gains on 7p12 and monosomy 10 in glioblastomas promotes tumorigenic epidermal growth factor (EGF) signaling through loss of...

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Share to Chromosomes, Human, Pair 10
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19602687
DOI: 10.1001/jama.2009.1022
PMCID: PMC3089898

Genes

ANXA7
EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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