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Article

DNA base excision repair gene polymorphisms modulate human cognitive performance and decline during normal life span.

Mechanisms of ageing and development - 1 Aug 2011

Lillenes Meryl S, Espeseth Thomas, Støen Mari, Lundervold Astri J, Frye Stephan A, Rootwelt Helge, Reinvang Ivar, Tønjum Tone

Abstract excerpt

To test the hypothesis that single nucleotide polymorphisms (SNPs) in DNA repair genes are associated with cognitive performance during normal aging, the relationship between SNPs in selected exons in DNA base excision repair (BER) genes and cognitive performance was examined in 712 healthy Norwegian individuals aged 20-75 years. SNPs examined included PolB(Pro242Arg), hOGG1(Ser326Cys), MutYH (Met22Val),...

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Source

Identifiers

PMID: 21884718
DOI: 10.1016/j.mad.2011.08.002

Genes

NEIL2
XRCC1
APOE
CHRNA4
NEIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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