Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog.

doi:10.1126/science.2188361

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Article

Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog.

Science (New York, N.Y.) - 18 May 1990

Gertler F B, Doctor J S, Hoffmann F M

Abstract excerpt

The Drosophila abelson (abl) gene encodes the homolog of the mammalian c-abl cytoplasmic tyrosine kinase and is an essential gene for the development of viable adult flies. Three second-site mutations that suppress the lethality caused by the absence of abl function have been isolated, and all th...

Topics

Animals
Drosophila
Enhancer Elements, Genetic
Eye
Genes, Lethal
Heterozygote
Homozygote
Larva
Microscopy, Electron
Mutation
Nervous System
Phenotype
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-abl
Suppression, Genetic

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