Article
Disabled is a bona fide component of the Abl signaling network.
Development (Cambridge, England) - 1 Nov 2010
Song Jeong K, Kannan Ramakrishnan, Merdes Gunter, Singh Jaskirat, Mlodzik Marek, Giniger Edward
Abstract excerpt
Abl is an essential regulator of cell migration and morphogenesis in both vertebrates and invertebrates. It has long been speculated that the adaptor protein Disabled (Dab), which is a key regulator of neuronal migration in the vertebrate brain, might be a component of this signaling pathway, but this idea has been controversial. We now demonstrate that null mutations of Drosophila Dab result in phenotypes that...
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