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Article

FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.

PLoS genetics - 1 Aug 2011

Kabashi Edor, Bercier Valérie, Lissouba Alexandra, Liao Meijiang, Brustein Edna, Rouleau Guy A, Drapeau Pierre

Abstract excerpt

Mutations in the SOD1 and TARDBP genes have been commonly identified in Amyotrophic Lateral Sclerosis (ALS). Recently, mutations in the Fused in sarcoma gene (FUS) were identified in familial (FALS) ALS cases and sporadic (SALS) patients. Similarly to TDP-43 (coded by TARDBP gene), FUS is an RNA binding protein. Using the zebrafish (Danio rerio), we examined the consequences of expressing human wild-type (WT) FUS...

Topics

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Amyotrophic Lateral Sclerosis
DNA-Binding Proteins
Epistasis, Genetic
Motor Activity
RNA-Binding Protein FUS

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Superoxide Dismutase

Superoxide Dismutase-1

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Open in PubMed Open full text

Identifiers

PMID: 21829392
DOI: 10.1371/journal.pgen.1002214
PMCID: PMC3150442

Genes

FUS
TARDBP
SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis.PMID 21829392Read ↗

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