Article
Gene amplification accompanied by the loss of a chromosome containing the native allele and the appearance of the amplified DNA at a new chromosomal location.
Proceedings of the National Academy of Sciences of the United States of America - 15 Sept 1991
Heard E, Williams S V, Sheer D, Fried M
Abstract excerpt
The organization of amplified DNA in mammalian cells in the form of inverted repeats rather than tandem repeats was first observed and studied in the 3B rat cell line. The structure and chromosomal location of the amplified inverted duplications in this cell line have been further analyzed by clo...
Topics
- Alleles
- Animals
- Blotting, Southern
- Cell Line
- Chromosome Mapping
- Cloning, Molecular
- DNA, Viral
- Gene Amplification
- Nucleic Acid Hybridization
- Oncogenes
- Polyomavirus
- Rats
- Restriction Mapping