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Article

The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS.

Nature - 17 Feb 2000

Millonig J H, Millen K J, Hatten M E

Abstract excerpt

In the vertebrate central nervous system (CNS), a cascade of signals that originates in the ectoderm adjacent to the neural tube is propagated by the roof plate to dorsalize the neural tube. Here we report that the phenotype of the spontaneous neurological mutant mouse dreher (dr) results from a failure of the roof plate to develop. Dorsalization of the neural tube is consequently affected: dorsal interneurons in...

Topics

Amino Acid Sequence
Animals
Central Nervous System
Chromosome Mapping
Cloning, Molecular
Crosses, Genetic
Homeodomain Proteins
LIM-Homeodomain Proteins
Mice
Mice, Inbred BALB C
Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Molecular Sequence Data

Mutation

Sequence Alignment

Transcription Factors

Source

Identifiers

PMID: 10693804
DOI: 10.1038/35001573

Provenance

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The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS.PMID 10693804Read ↗

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Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system.Semantic proximity Read ↗

Purkinje cell compartmentalization in the cerebellum of the spontaneous mutant mouse dreher.Semantic proximity Read ↗

Dorsal patterning defects in the hindbrain, roof plate and skeleton in the dreher (dr(J)) mouse mutant.Semantic proximity Read ↗

Mutation at the Lmx1a locus provokes aberrant brain development in the rat.Semantic proximity Read ↗

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Defective Neural Tube Closure and Anteroposterior Patterning in Mice Lacking the LIM Protein LMO4 or Its Interacting Partner Deaf-1Semantic proximity Read ↗

Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.Semantic proximity Read ↗

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