Article
Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.
Clinical epigenetics - 1 Jan 2018
Lin Ming-En, Hou Hsin-An, Tsai Cheng-Hong, Wu Shang-Ju, Kuo Yuan-Yeh, Tseng Mei-Hsuan, Liu Ming-Chih, Liu Chia-Wen, Chou Wen-Chien, Chen Chien-Yuan, Tang Jih-Luh, Yao Ming, Li Chi-Cheng, Huang Shang-Yi, Ko Bor-Sheng, Hsu Szu-Chun, Lin Chien-Ting, Tien Hwei-Fang
Abstract excerpt
Background: DNMT3A gene mutation has been associated with poor prognosis in acute myeloid leukemia, but its clinical implications in myelodysplastic syndrome (MDS) and dynamic changes during disease progression remain controversial. Results: In this study, DNMT3A mutation was identified in 7.9% of 469 de novo MDS patients. DNMT3A-mutated patients had higher platelet counts at diagnosis, and patients with ring...
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