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Article

Sox4 cooperates with PU.1 haploinsufficiency in murine myeloid leukemia

31 Aug 2011

Abstract excerpt

Cooperation of multiple mutations is thought to be required for cancer development. In previous studies, murine myeloid leukemias induced by transducing wild-type bone marrow progenitors with a SRY sex determining region Y-box 4 (Sox4)-expressing retrovirus frequently carried proviral insertions at Sfpi1, decreasing its mRNA levels, suggesting that reduced Sfpi1 expression cooperates with Sox4 in myeloid leukemia...

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Identifiers

PMID: 21878674
DOI: 10.1182/blood-2011-04-351528

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