Article
Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.
The Journal of biological chemistry - 8 Aug 2003
Beck Sabine, Lambeau Gérard, Scholz-Pedretti Kristen, Gelb Michael H, Janssen Marcel J W, Edwards Suzanne H, Wilton David C, Pfeilschifter Josef, Kaszkin Marietta
Abstract excerpt
In rat mesangial cells, exogenously added secreted phospholipases A2 (sPLA2s) potentiate the expression of pro-inflammatory sPLA2-IIA first induced by cytokines like tumor necrosis factor-alpha (TNFalpha) and interleukin-1 beta. The transcriptional pathway mediating this effect is, however, unknown. Because products of PLA2 activity are endogenous activators of peroxisome proliferator-activated receptor alpha...
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