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Article

The DSL ligand APX-1 is required for normal ovulation in C. elegans.

Developmental biology - 15 Mar 2018

McGovern Marie, Castaneda Perla Gisela, Pekar Olga, Vallier Laura G, Cram Erin J, Hubbard E Jane Albert

Abstract excerpt

DSL ligands activate the Notch receptor in many cellular contexts across metazoa to specify cell fate. In addition, Notch receptor activity is implicated in post-mitotic morphogenesis and neuronal function. In C. elegans, the DSL family ligand APX-1 is expressed in a subset of cells of the proximal gonad lineage, where it can act as a latent proliferation-promoting signal to maintain proximal germline tumors....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29371032
DOI: 10.1016/j.ydbio.2018.01.009
PMCID: PMC5957500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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