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Article

A novel function for the presenilin family member spe-4: inhibition of spermatid activation in Caenorhabditis elegans.

BMC developmental biology - 22 Apr 2008

Gosney Ryoko, Liau Wei-Siang, Lamunyon Craig W

Abstract excerpt

BACKGROUND: Sperm cells must regulate the timing and location of activation to maximize the likelihood of fertilization. Sperm from most species, including the nematode Caenorhabditis elegans, activate upon encountering an external signal. Activation for C. elegans sperm occurs as spermatids undergo spermiogenesis, a profound cellular reorganization that produces a pseudopod. Spermiogenesis is initiated by an...

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Identifiers

PMID: 18430247
DOI: 10.1186/1471-213X-8-44
PMCID: PMC2383881

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A novel function for the presenilin family member spe-4: inhibition of spermatid activation in Caenorhabditis elegans.PMID 18430247Read ↗

Premature sperm activation and defective spermatogenesis caused by loss of spe-46 function in Caenorhabditis elegans.Semantic proximity Read ↗

spe-29 encodes a small predicted membrane protein required for the initiation of sperm activation in Caenorhabditis elegans.Semantic proximity Read ↗

A New Player in the Spermiogenesis Pathway of Caenorhabditis elegans.Semantic proximity Read ↗

Spermiogenesis initiation in Caenorhabditis elegans involves a casein kinase 1 encoded by the spe-6 gene.Semantic proximity Read ↗

Subcellular patterns of SPE-6 localization reveal unexpected complexities in Caenorhabditis elegans sperm activation and sperm function.Semantic proximity Read ↗

spe-43 is required for sperm activation in C. elegans.Semantic proximity Read ↗

The genetic and molecular analysis of spe-19, a gene required for sperm activation in Caenorhabditis elegans.Semantic proximity Read ↗

spe-12 encodes a sperm cell surface protein that promotes spermiogenesis in Caenorhabditis elegans.Semantic proximity Read ↗

The Caenorhabditis elegans spe‐49 gene is required for fertilization and encodes a sperm‐specific transmembrane protein homologous to SPE‐42Semantic proximity Read ↗

The Caenorhabditis elegans spe-38 gene encodes a novel four-pass integral membrane protein required for sperm function at fertilization.Semantic proximity Read ↗

SPE-44 Implements Sperm Cell FateSemantic proximity Read ↗

SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans.Semantic proximity Read ↗

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