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Article

Relationship of 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase gene polymorphisms with metabolic syndrome and type 2 diabetes.

Endocrine journal - 1 Jan 2011

Moon Seong-Su, Lee Young-Sil, Kim Jung-Guk, Kim Su-Won, Jeong Ji-Yun, Jeon Eon-Ju, Seo Hyun-Ae, Kwak Soo Heon, Park Kyong Soo, Lee In-Kyu

Abstract excerpt

11β-Hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive glucocorticoid to active glucocorticoid, plays a critical role in the pathogenesis of visceral obesity, metabolic syndrome, and diabetes. Hexose-6-phosphate dehydrogenase (H6PD) supplies a crucial cofactor, reduced nicotinamide adenine dinucleotide phosphate (NADPH), which allows HSD11B1 to maintain reductase activity. The association of...

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PMID: 21869537
DOI: 10.1507/endocrj.ej11-0035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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