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Article

Association between a 11β-hydroxysteroid dehydrogenase type 1 gene polymorphism and metabolic syndrome in a South Indian population.

Metabolic syndrome and related disorders - 1 Dec 2013

Gandhi Kunal, Adhikari Prabha, Basu Arindam, Achappa Basavaprabhu

Abstract excerpt

INTRODUCTION: The striking phenotypic similarities between metabolic syndrome and the Cushing syndrome of glucocorticoid excess have often been linked to 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which activates inert precursors like the cortisone, 11-dehydrocortisone to active glucocorticoids by oxo-reductase activity in several organs. Thus, increased expression of 11β-HSD1 is associated with insulin...

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PMID: 23869418
DOI: 10.1089/met.2013.0049

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