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Article

The tobacco carcinogen nitrosamine induces a differential gene expression response in tumour susceptible A/J and resistant C3H mouse lungs.

European journal of cancer (Oxford, England : 1990) - 1 Feb 2013

Gordon William, Galitovskiy Valentin, Edwards Robert, Andersen Bogi, Grando Sergei A

Abstract excerpt

The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), an important carcinogen found in tobacco products, causes lung cancer in genetically susceptible animals. In addition to mutations of the K-Ras gene, NNK has non-mutagenic effects that include alterations in gene expression and immunomodulation in the lung. Here we report the identification of two gene sets associated with NNK-induced pulmonary...

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Source

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Identifiers

PMID: 23010150
DOI: 10.1016/j.ejca.2012.08.027
PMCID: PMC3587785

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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