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Article

Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants.

The Journal of biological chemistry - 25 Feb 1994

Kobayashi T, Tao T, Gergely J, Collins J H

Abstract excerpt

Ca2+ regulation of vertebrate-striated muscle contraction is initiated by conformational changes in the Ca(2+)-binding protein troponin C (TnC) and subsequent changes in the interaction of TnC with the inhibitory protein TnI. We have constructed mutants of rabbit skeletal muscle TnC in which natural Cys-98 was replaced by Leu, and a single Cys residue was introduced at position 12 (TnC12) or 89 (TnC89). Cys...

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PMID: 8119911

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Structure of the troponin complex. Implications of photocross-linking of troponin I to troponin C thiol mutants.PMID 8119911Read ↗

Identification of the photocrosslinking sites in troponin-I with 4-maleimidobenzophenone labelled mutant troponin-Cs having single cysteines at positions 158 and 21.Semantic proximity Read ↗

Photocrosslinking of benzophenone-labeled single cysteine troponin I mutants to other thin filament proteins.Semantic proximity Read ↗

Ca2(+)-dependent interactions between the C-helix of troponin-C and troponin-I. Photocross-linking and fluorescence studies using a recombinant troponin-C.Semantic proximity Read ↗

Proximity relationships between residue 117 of rabbit skeletal troponin-I and residues in troponin-C and actin.Semantic proximity Read ↗

Inhibition of mutant troponin C activity by an intra-domain disulphide bond.Semantic proximity Read ↗

Ca2+-dependent interaction of the inhibitory region of troponin I with acidic residues in the N-terminal domain of troponin C.Semantic proximity Read ↗

Troponin-I interacts with the Met47 region of skeletal muscle actin. Implications for the mechanism of thin filament regulation by calcium.Semantic proximity Read ↗

Probing the calcium-induced conformational transition of troponin C with site-directed mutants.Semantic proximity Read ↗

Switch action of troponin on muscle thin filament as revealed by spin labeling and pulsed EPR.Semantic proximity Read ↗

Structural and functional studies on Troponin I and Troponin C interactions.Semantic proximity Read ↗

Disparate fluorescence properties of 2-[4'-(iodoacetamido)anilino]-naphthalene-6-sulfonic acid attached to Cys-84 and Cys-35 of troponin C in cardiac muscle troponin.Semantic proximity Read ↗

Ca(2+) induces an extended conformation of the inhibitory region of troponin I in cardiac muscle troponin.Semantic proximity Read ↗

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