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Article

Frequency of the C1236T, G2677T/A and C3435T MDR1 gene polymorphisms in the Serbian population.

Pharmacological reports : PR - 1 Jan 2011

Milojkovic Maja, Stojnev Slavica, Jovanovic Ivan, Ljubisavljevic Srdjan, Stefanovic Vladisav, Sunder-Plassman Raute

Abstract excerpt

The multi-drug resistance 1 (MDR1) gene encodes for a P-glycoprotein (PGP), which acts as a gate-keeper against various kinds of xenobiotics. Several single nucleotide polymorphisms (SNPs) in the MDR1 gene that may influence PGP level and function have been identified. The aim of this study was to simultaneously analyze the three most important MDR1 SNPs, C3435T, G2677T/A and C1236T, in the Serbian population and...

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PMID: 21857092
DOI: 10.1016/s1734-1140(11)70593-x

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PGP

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