Article
ACTH-induced hypertension is dependent on the ouabain-binding site of the alpha2-Na+-K+-ATPase subunit.
American journal of physiology. Heart and circulatory physiology - 1 Jul 2008
Lorenz John N, Loreaux Elizabeth L, Dostanic-Larson Iva, Lasko Valerie, Schnetzer J Renee, Paul Richard J, Lingrel Jerry B
Abstract excerpt
ACTH-induced-hypertension is commonly employed as a model of stress-related hypertension, and despite extensive investigation, the mechanisms underlying elevated blood pressure (BP) are not well understood. We have reported that ACTH treatment increases tail-cuff systolic pressure in wild-type mice but not in mutant mice expressing ouabain-resistant alpha(2)-Na(+)-K(+)-ATPase subunits (alpha2(R/R) mice). Since...
Topics
- Adrenergic beta-Agonists
- Adrenocorticotropic Hormone
- Aldosterone
- Animals
- Binding Sites
- Blood Pressure
- Blood Pressure Monitoring, Ambulatory
- Cerebrovascular Circulation
- Corticosterone
- Disease Models, Animal