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Article

Brain tissue volumes by APOE genotype and leisure activity-the AGES-Reykjavik Study.

Neurobiology of aging - 1 Apr 2012

Hafsteinsdottir Sigridur Harpa, Eiriksdottir Gudny, Sigurdsson Sigurdur, Aspelund Thor, Harris Tamara B, Launer Lenore J, Gudnason Vilmundur

Abstract excerpt

This study investigates the association of the APOE ε4 allele and leisure activity with brain tissue volumes, including white matter hyperintensities (WMH), in a population-based cohort of 4303 nondemented individuals, aged 66-96 years. APOE ε4 carriers were shown to have greater WMH and cerebrospinal fluid (CSF) volumes than noncarriers but smaller gray matter (GM) volumes. There was no significant difference in...

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Identifiers

PMID: 21856047
DOI: 10.1016/j.neurobiolaging.2011.06.028
PMCID: PMC4821657

Genes

APOE
TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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