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Article

Toll-like receptor 4 single-nucleotide polymorphisms Asp299Gly and Thr399Ile in head and neck squamous cell carcinomas.

Journal of translational medicine - 21 Aug 2011

Bergmann Christoph, Bachmann Hagen S, Bankfalvi Agnes, Lotfi Ramin, Pütter Carolin, Wild Clarissa A, Schuler Patrick J, Greve Jens, Hoffmann Thomas K, Lang Stephan, Scherag André, Lehnerdt Götz F

Abstract excerpt

BACKGROUND: Chronic inflammation plays an important role in head and neck squamous cell carcinomas (HNSCC). This study addresses the impact of two single nucleotide polymorphisms (SNP) Asp299Gly and Thr399Ile of the toll-like receptor (TLR) 4 gene on the clinical outcome while accounting for the influence of adjuvant systemic therapy in a large cohort of HNSCC patients. METHODS: Genotype analysis was done using...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21854645
DOI: 10.1186/1479-5876-9-139
PMCID: PMC3170603

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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