Article
A high IL-4 production diplotype is associated with an increased risk but better prognosis of oral and pharyngeal carcinomas.
Archives of oral biology - 1 Jan 2014
Yang Cheng-Mei, Chen Hung-Chih, Hou Yu-Yi, Lee Ming-Chien, Liou Huei-Han, Huang Sin-Jhih, Yen Liang-Ming, Eng Dong-Mei, Hsieh Yao-Dung, Ger Luo-Ping
Abstract excerpt
OBJECTIVE: Interleukin (IL)-4 is a key cytokine in humoral and adaptive immunity. This study aimed to evaluate the association of IL-4 genetic variants (-590C>T and VNTR in intron 3) with the risk and prognosis of oral and pharyngeal squamous cell carcinoma (OPSCC). DESIGN: A total of 1215 subjects, which included 623 healthy controls and 592 OPSCC cases (463 oral squamous cell carcinoma (OSCC) and 129 pharyngeal...
Topics
- Adult
- Alcohol Drinking
- Areca
- Carcinoma, Squamous Cell
- Case-Control Studies
- Female
- Genotype
- Humans
- Interleukin-4
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Mouth Neoplasms
- Neoplasm Recurrence, Local