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Article

A high IL-4 production diplotype is associated with an increased risk but better prognosis of oral and pharyngeal carcinomas.

Archives of oral biology - 1 Jan 2014

Yang Cheng-Mei, Chen Hung-Chih, Hou Yu-Yi, Lee Ming-Chien, Liou Huei-Han, Huang Sin-Jhih, Yen Liang-Ming, Eng Dong-Mei, Hsieh Yao-Dung, Ger Luo-Ping

Abstract excerpt

OBJECTIVE: Interleukin (IL)-4 is a key cytokine in humoral and adaptive immunity. This study aimed to evaluate the association of IL-4 genetic variants (-590C>T and VNTR in intron 3) with the risk and prognosis of oral and pharyngeal squamous cell carcinoma (OPSCC). DESIGN: A total of 1215 subjects, which included 623 healthy controls and 592 OPSCC cases (463 oral squamous cell carcinoma (OSCC) and 129 pharyngeal...

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PMID: 24169152
DOI: 10.1016/j.archoralbio.2013.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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