Article
Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections.
Annals of the rheumatic diseases - 1 Jun 2009
Dieguez-Gonzalez R, Calaza M, Shi D, Meulenbelt I, Loughlin J, Tsezou A, Dai J, Malizos K N, Slagboom E P, Kloppenburg M, Chapman K, Jiang Q, Kremer D, Gomez-Reino J J, Nakajima N, Ikegawa S, Gonzalez A
Abstract excerpt
OBJECTIVES: To replicate a previously reported association with osteoarthritis (OA) of the promoter single nucleotide polymorphism (SNP) rs10980705 in the endothelial differentiation gene 2 (EDG2). METHODS: Five collections of samples, four from Europe and one from China, were studied. They included patients with 3 OA phenotypes: 1501 with knee OA, 1497 with hip OA and 376 with generalised OA. A total of 2521...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.