Article
TIMP-2 SNPs rs7342880 and rs4789936 are linked to risk of knee osteoarthritis in the Chinese Han Population.
Oncotarget - 3 Jan 2017
Xu Pengcheng, Guo Wen, Jin Tianbo, Wang Jihong, Fan Dongsheng, Hao Zengtao, Jing Shangfei, Han ChaoQian, Du Jieli, Jiang Dong, Wen Shuzheng, Wang Jianzhong
Abstract excerpt
This study aimed to investigate whether functional polymorphisms in the tissue inhibitors of metalloproteinase-2 (TIMP-2) gene are associated with susceptibility to knee osteoarthritis (OA) in the Chinese Han population. Six TIMP-2 single nucleotide polymorphisms (SNPs) were assayed using MassARRAY in 300 patients clinically and radiographically diagnosed with knee OA and in 428 controls. Allelic and genotypic...
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