Article
Autoimmune disease classification by inverse association with SNP alleles.
PLoS genetics - 1 Dec 2009
Sirota Marina, Schaub Marc A, Batzoglou Serafim, Robinson William H, Butte Atul J
Abstract excerpt
With multiple genome-wide association studies (GWAS) performed across autoimmune diseases, there is a great opportunity to study the homogeneity of genetic architectures across autoimmune disease. Previous approaches have been limited in the scope of their analysis and have failed to properly incorporate the direction of allele-specific disease associations for SNPs. In this work, we refine the notion of a...
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