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Article

Genome transplantation in bacteria: changing one species to another.

Science (New York, N.Y.) - 3 Aug 2007

Lartigue Carole, Glass John I, Alperovich Nina, Pieper Rembert, Parmar Prashanth P, Hutchison Clyde A, Smith Hamilton O, Venter J Craig

Abstract excerpt

As a step toward propagation of synthetic genomes, we completely replaced the genome of a bacterial cell with one from another species by transplanting a whole genome as naked DNA. Intact genomic DNA from Mycoplasma mycoides large colony (LC), virtually free of protein, was transplanted into Mycoplasma capricolum cells by polyethylene glycol-mediated transformation. Cells selected for tetracycline resistance,...

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Share to DNA, Bacterial
Share to Genome, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polyethylene Glycols

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Share to Recombination, Genetic

Share to Sequence Analysis, DNA

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Source

Identifiers

PMID: 17600181
DOI: 10.1126/science.1144622

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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