Article
Tet protein domains interact productively to mediate tetracycline resistance when present on separate polypeptides.
Journal of bacteriology - 1 Jul 1991
Rubin R A, Levy S B
Abstract excerpt
Both domains, alpha and beta, of the cytoplasmic membrane-localized Tet proteins encoded by the tet gene family (classes A through E) are required for resistance to tetracycline (Tcr) in gram-negative bacteria. Two inactive proteins, each containing a mutation in the opposite domain, are capable...
Topics
- Amino Acid Sequence
- Base Sequence
- Escherichia coli
- Frameshift Mutation
- Genes, Bacterial
- Genetic Complementation Test
- Genotype
- Macromolecular Substances
- Microbial Sensitivity Tests
- Molecular Sequence Data
- R Factors
- Repressor Proteins
- Restriction Mapping
- Tetracycline
- Tetracycline Resistance