Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tet protein domains interact productively to mediate tetracycline resistance when present on separate polypeptides.

Journal of bacteriology - 1 Jul 1991

Rubin R A, Levy S B

Abstract excerpt

Both domains, alpha and beta, of the cytoplasmic membrane-localized Tet proteins encoded by the tet gene family (classes A through E) are required for resistance to tetracycline (Tcr) in gram-negative bacteria. Two inactive proteins, each containing a mutation in the opposite domain, are capable of complementation to produce Tcr. Similarly, inactive hybrid proteins expressed by interdomain gene hybrids...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Bacterial

Share to Genetic Complementation Test

Share to Genotype

Share to Molecular Sequence Data

Share to Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 2066343
DOI: 10.1128/jb.173.14.4503-4509.1991
PMCID: PMC208114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tet protein domains interact productively to mediate tetracycline resistance when present on separate polypeptides.PMID 2066343Read ↗

Interdomain hybrid Tet proteins confer tetracycline resistance only when they are derived from closely related members of the tet gene family.Semantic proximity Read ↗

Evidence for interactions between helices 5 and 8 and a role for the interdomain loop in tetracycline resistance mediated by hybrid Tet proteins.Semantic proximity Read ↗

Twin arginine translocation (Tat)-dependent export in the apparent absence of TatABC or TatA complexes using modified Escherichia coli TatA subunits that substitute for TatB.Semantic proximity Read ↗

Hybrid genes over-express pertactin from Bordetella pertussis.Semantic proximity Read ↗

Expression and function of gamma delta- and alpha beta-T cell receptor heterodimers on human somatic T cell hybrids.Semantic proximity Read ↗

Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ.Semantic proximity Read ↗

Maltose-binding protein interacts simultaneously and asymmetrically with both subunits of the Tar chemoreceptor.Semantic proximity Read ↗

A ToxR-based dominant-negative system to investigate heterotypic transmembrane domain interactions.Semantic proximity Read ↗

Small clusters of divergent amino acids surrounding the effector domain mediate the varied phenotypes of EF-G and LepA expression.Semantic proximity Read ↗

Mutations in subunits of the Escherichia coli twin-arginine translocase block function via differing effects on translocation activity or tat complex structure.Semantic proximity Read ↗

Phenotypes of combined tet repressor mutants for effector and operator recognition and allostery.Semantic proximity Read ↗

Purification and characterization of Tet(M), a protein that renders ribosomes resistant to tetracycline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.