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Article

Population differences in platinum toxicity as a means to identify novel genetic susceptibility variants.

Pharmacogenetics and genomics - 1 May 2010

O'Donnell Peter H, Gamazon Eric, Zhang Wei, Stark Amy L, Kistner-Griffin Emily O, Stephanie Huang R, Eileen Dolan M

Abstract excerpt

OBJECTIVES: Clinical studies show that Asians (ASN) are more susceptible to toxicities associated with platinum-containing regimens. We hypothesized that studying ASN as an 'enriched phenotype' population could enable the discovery of novel genetic determinants of platinum susceptibility. METHODS: Using well-genotyped lymphoblastoid cell lines from the HapMap, we determined cisplatin and carboplatin cytotoxicity...

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Identifiers

PMID: 20393316
DOI: 10.1097/FPC.0b013e3283396c4e
PMCID: PMC2908307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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