The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneri.

doi:10.1128/jb.172.11.6274-6281.1990

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Article

The two-component regulatory system ompR-envZ controls the virulence of Shigella flexneri.

Journal of bacteriology - 1 Nov 1990

Bernardini M L, Fontaine A, Sansonetti P J

Abstract excerpt

In Shigella flexneri, the ompB locus (containing the ompR and envZ genes) was found to modulate expression of the vir genes, which are responsible for invasion of epithelial cells. vir gene expression was markedly enhanced under conditions of high osmolarity (300 mosM), similar to that encountere...

Topics

Cloning, Molecular
Escherichia coli
HeLa Cells
Humans
Mutation
Operon
Phenotype
Plasmids
Restriction Mapping
Shigella flexneri
Virulence
beta-Galactosidase

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