Article
DNA twist, flexibility and transcription of the osmoregulated proU promoter of Salmonella typhimurium.
The EMBO journal - 15 Nov 1995
Jordi B J, Owen-Hughes T A, Hulton C S, Higgins C F
Abstract excerpt
Transcription from many bacterial promoters is sensitive to the level of DNA supercoiling. We have investigated the mechanism by which environmentally induced changes in DNA supercoiling might regulate transcription. For the proU promoter of Salmonella typhimurium, osmotically induced changes in DNA topology appear to play a primary regulatory role. Changes in DNA supercoiling (linking number; delta Lk) are...
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