Studies on mutagenicity of 2 bronchodilators under development in Cuba.

doi:10.1016/0165-1218(83)90123-4

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Article

Studies on mutagenicity of 2 bronchodilators under development in Cuba.

Mutation research - 1 Jan 2000

Jiménez M A, Torroella M, Fernández S I, Pellón R

Abstract excerpt

2 pyridoquinazolones, 2-amino-11H-pyrido[2,1-b]quinazolin-11-one (2-APQ) and 11H-pyrido[2,1-b]quinazolin-11-one (PQ), under development as anti-asthma drugs, were studied for mutagenicity. 2-APQ was found to be a strong mutagen in 5 strains of Salmonella typhimurium and a mild one in the forward-...

Topics

Animals
Biotransformation
Bronchodilator Agents
Male
Microsomes, Liver
Mutagenicity Tests
Mutagens
Mutation
Quinazolines
Rats
Rats, Inbred Strains
Salmonella typhimurium
Schizosaccharomyces
Species Specificity
Structure-Activity Relationship

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