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Free cholesterol accumulation impairs antioxidant activities and aggravates apoptotic cell death in menadione-induced oxidative injury.

Archives of biochemistry and biophysics - 1 Oct 2011

Lee Waisin, Xu Mingjing, Li Yue, Gu Yong, Chen Jianping, Wong Derek, Fung Peter C W, Shen Jiangang

Abstract excerpt

Although the relationship between hypercholesterolemia and oxidative stress has been extensively investigated, direct evidence regarding to the roles of cholesterol accumulation in the generations of reactive oxygen species (ROS) and apoptotic cell death under oxidative stress is lack. In this study, we investigated productions of superoxide anions (O(2)(-)) and nitric oxide (NO), and apoptotic cell death in wild...

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PMID: 21843500
DOI: 10.1016/j.abb.2011.07.014

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