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p53 codon 72 polymorphism is associated with susceptibility to hepatocellular carcinoma in the Turkish population: a case-control study.

Molecular biology reports - 1 Feb 2012

Sümbül Ahmet Taner, Akkız Hikmet, Bayram Süleyman, Bekar Aynur, Akgöllü Ersin, Sandıkçı Macit

Abstract excerpt

The tumor suppressor p53 gene plays a crucial role in preventing carcinogenesis through its ability to induce cell cycle arrest and apoptosis following DNA damage and oncogene activation. A guanine (G)/cytosine (C) common single nucleotide polymorphism (SNP) at second position of codon 72 in exon 4 of p53 gene determines a arginine (Arg) to proline (Pro) (Arg72Pro) aminoacidic substitution within the proline-rich...

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PMID: 21607615
DOI: 10.1007/s11033-011-0903-2

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