Article
The mutagenic activity of ethylmethanesulphonate, benzidine and benzo[a]pyrene at the hprt locus of wild-type L5178Y mouse lymphoma cells.
Mutagenesis - 1 Jan 1990
Kennelly J C, Clare C B, Campbell J, Lane M P, Harrington D H, Cole H, Garner R C
Abstract excerpt
Ethylmethanesulphonate (EMS), benzidine (BZD) and benzo[a]pyrene (B[a]P) were assayed for ability to induce mutation at the hprt locus of wild-type L5178Y mouse lymphoma cells. EMS was assayed in the absence of metabolic activation, B[a]P in the presence of metabolic activation (S-9 mix) and BZD...
Topics
- Animals
- Benzidines
- Benzo(a)pyrene
- Biotransformation
- Cell Survival
- Ethyl Methanesulfonate
- Hypoxanthine Phosphoribosyltransferase
- Leukemia L5178
- Mice
- Microsomes, Liver
- Mutagenicity Tests
- Mutagens
- Mutation
- Tumor Cells, Cultured