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Article

Encoding phenotype in bacteria with an alternative genetic set.

Journal of the American Chemical Society - 16 Nov 2011

Krueger Andrew T, Peterson Larryn W, Chelliserry Jijumon, Kleinbaum Daniel J, Kool Eric T

Abstract excerpt

An unnatural base-pair architecture with base pairs 2.4 Å larger than the natural DNA-based genetic system (xDNA) is evaluated for its ability to function like DNA, encoding amino acids in the context of living cells. xDNA bases are structurally analogous to natural bases but homologated by the width of a benzene ring, increasing their sizes and resulting in a duplex that is wider than native B-DNA. Plasmids...

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Identifiers

PMID: 21981660
DOI: 10.1021/ja208025e
PMCID: PMC3255458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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