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Article

Crucial importance of the water-entropy effect in predicting hot spots in protein-protein complexes.

Physical chemistry chemical physics : PCCP - 28 Sept 2011

Oshima Hiraku, Yasuda Satoshi, Yoshidome Takashi, Ikeguchi Mitsunori, Kinoshita Masahiro

Abstract excerpt

"Hot spots" are residues accounting for the majority of the protein-protein binding free energy (BFE) despite that they comprise only a small fraction of the protein-protein interface. A hot spot can be found experimentally by measuring the BFE change upon mutating it to alanine: the mutation gives rise to a significantly large increase in the BFE. Theoretical prediction of hot spots is an enthusiastic subject in...

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PMID: 21842056
DOI: 10.1039/c1cp21597c

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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