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Article

Magnitude of the hydrophobic effect at central versus peripheral sites in protein-protein interfaces.

Structure (London, England : 1993) - 1 Feb 2005

Li Yili, Huang Yuping, Swaminathan Chittoor P, Smith-Gill Sandra J, Mariuzza Roy A

Abstract excerpt

Hydrophobic interactions are essential for stabilizing protein-protein complexes, whose interfaces generally consist of a central cluster of hot spot residues surrounded by less important peripheral residues. According to the O-ring hypothesis, a condition for high affinity binding is solvent exclusion from interacting residues. This hypothesis predicts that the hydrophobicity at the center is significantly...

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PMID: 15698573
DOI: 10.1016/j.str.2004.12.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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