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Article

Co-Occurring Atomic Contacts for the Characterization of Protein Binding Hot Spots.

PloS one - 1 Jan 2015

Liu Qian, Ren Jing, Song Jiangning, Li Jinyan

Abstract excerpt

A binding hot spot is a small area at a protein-protein interface that can make significant contribution to binding free energy. This work investigates the substantial contribution made by some special co-occurring atomic contacts at a binding hot spot. A co-occurring atomic contact is a pair of atomic contacts that are close to each other with no more than three covalent-bond steps. We found that two kinds of...

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Identifiers

PMID: 26675422
DOI: 10.1371/journal.pone.0144486
PMCID: PMC4684219

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