Article
Molecular insight into the association between cartilage regeneration and ear wound healing in genetic mouse models: targeting new genes in regeneration.
G3 (Bethesda, Md.) - 6 Nov 2013
Rai Muhammad Farooq, Schmidt Eric J, McAlinden Audrey, Cheverud James M, Sandell Linda J
Abstract excerpt
Tissue regeneration is a complex trait with few genetic models available. Mouse strains LG/J and MRL are exceptional healers. Using recombinant inbred strains from a large (LG/J, healer) and small (SM/J, nonhealer) intercross, we have previously shown a positive genetic correlation between ear wound healing, knee cartilage regeneration, and protection from osteoarthritis. We hypothesize that a common set of genes...
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