Repressive chromatin affects factor binding at yeast HO (homothallic switching) promoter.

doi:10.1074/jbc.M111.281626

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Article

Repressive chromatin affects factor binding at yeast HO (homothallic switching) promoter.

The Journal of biological chemistry - 7 Oct 2011

Takahata Shinya, Yu Yaxin, Stillman David J

Abstract excerpt

The yeast HO gene is tightly regulated, with multiple activators and coactivators needed to overcome repressive chromatin structures that form over this promoter. Coactivator binding is strongly interdependent, as loss of one factor sharply reduces recruitment of other factors. The Rpd3(L) histone deacetylase is recruited to HO at two distinct times during the cell cycle, first by Ash1 to the URS1 region of the...

Topics

CDC28 Protein Kinase, S cerevisiae
Cell Cycle
Chromatin
Deoxyribonucleases, Type II Site-Specific
Endonucleases
Gene Expression Regulation, Fungal
Histone Deacetylases
Mutation
Nucleosomes
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Repressor Proteins

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

TATA Box

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21840992
DOI: 10.1074/jbc.M111.281626
PMCID: PMC3186355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-21840992-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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