Article
Identification of asymmetrically localized determinant, Ash1p, required for lineage-specific transcription of the yeast HO gene.
Cell - 8 Mar 1996
Sil A, Herskowitz I
Abstract excerpt
S. cerevisiae cells exhibit asymmetric determination of cell fate. Cell division yields a mother cell, which is competent to transcribe the HO gene and switch mating type, and a daughter cell, which is not. We have isolated a mutant in which daughters transcribe HO and switch mating type. This mutation defines the ASH1 gene (asymmetric synthesis of HO). Deletion and overexpression of ASH1 cause reciprocal cell...
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