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Article

Effects of Wbp2 gene activation and the modifier Cdh23ahl on progressive hearing loss in Wbp2 mouse mutants.

Hearing research - 1 Oct 2026

Kumar Rechal, Pentland Daniel R, Ingham Neil J, Lewis Morag A, Martelletti Elisa, Steel Karen P

Abstract excerpt

Synapses are thought to be a vulnerable site in hearing loss. One gene required for normal synapse maintenance is Wbp2, which encodes a transcriptional co-activator of oestrogen and progesterone receptors. The Wbp2tm2a mouse mutant allele knocks down transcription to minimal levels and leads to progressive increase in ABR thresholds for high frequencies from 4 weeks onwards in homozygotes. This is accompanied by...

Read the complete abstract on PubMed

Topics

Animals
Cadherins
Hearing Loss
Auditory Threshold
Mutation
Phenotype
Cadherin Related Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Evoked Potentials, Auditory, Brain Stem

Hearing

Mice

Disease Models, Animal

Homozygote

Synapses

Disease Progression

Female

Auditory Acuity

Mice, Inbred C57BL

Hair Cells, Auditory, Inner

Source

Identifiers

PMID: 42531911
DOI: 10.1016/j.heares.2026.109754

Genes

ABR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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