Article
Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.
Science (New York, N.Y.) - 24 Aug 2001
Wu Y, Marsh J W
Abstract excerpt
The quiescent nature of most peripheral T cells poses an effective limitation to human immunodeficiency virus (HIV) replication and, in particular, to viral integration into the host chromatin. Two HIV proteins, Nef and Tat, increase T cell activity, but a requirement of integration for viral gene expression would preclude a role for these proteins in resting cells. Here, we report that HIV infection leads to...
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