Article
Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G Mouse Model Linked to Hypertrophic Cardiomyopathy.
Circulation. Heart failure - 1 Nov 2019
Ryba David M, Warren Chad M, Karam Chehade N, Davis Robert T, Chowdhury Shamim A K, Alvarez Manuel G, McCann Maximilian, Liew Chong Wee, Wieczorek David F, Varga Peter, Solaro R John, Wolska Beata M
Abstract excerpt
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder, primarily involving mutations in sarcomeric proteins. HCM patients present with hypertrophy, diastolic dysfunction, and fibrosis, but there is no specific treatment. The sphingosine-1-phosphate receptor modulator, FTY720/fingolimod, is approved for treatment of multiple sclerosis. We hypothesize that modulation of the...
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