Article
Association of tumor necrosis factor alpha-308 promoter polymorphism with spondyloarthritides patients in Colombia.
Rheumatology international - 1 Jul 2012
Romero-Sánchez C, Londoño J, Delgado G, Jaimes D A, De Avila J, Mora A, Avila M, Castellanos J, Briceño I, Valle-Oñate R
Abstract excerpt
The pathogenesis of SpA is considered to be a complex and multi-factorial process and, similar to other autoimmune diseases, includes the activity of proinflammatory cytokines such as TNF alpha. Our study compared the -308 promoter polymorphism of TNF alpha with TNF alpha levels, HLA-B27 status, age at the onset of symptoms, SpA subtype and the clinical degree of activity in Colombian SpA patients and healthy...
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