Article
Association between tumor necrosis factor-alpha gene promoter polymorphism at position -308 and acne in Turkish patients.
Archives of dermatological research - 1 Aug 2008
Baz Kiymet, Emin Erdal M, Yazici Ayça Cordan, Söylemez Fatma, Güvenç Ulaş, Taşdelen Bahar, Ikizoğlu Güliz
Abstract excerpt
Acne is a multifactorial, chronic inflammatory disease of pilosebaceous unit in which cytokines have been implicated in the pathogenesis. Although it is thought to be an inherited disease, there are limited data supporting the relevant genetic elements. Tumor necrosis factor-alpha (TNF-alpha) is one of the proinflammatory cytokines involved in the acne pathogenesis. Several single-nucleotide polymorphisms (SNPs)...
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