Article
HIV-1 resistance patterns to integrase inhibitors in antiretroviral-experienced patients with virological failure on raltegravir-containing regimens.
The Journal of antimicrobial chemotherapy - 1 Jun 2010
da Silva Daniel, Van Wesenbeeck Liesbeth, Breilh Dominique, Reigadas Sandrine, Anies Guerric, Van Baelen Kurt, Morlat Philippe, Neau Didier, Dupon Michel, Wittkop Linda, Fleury Hervé, Masquelier Bernard
Abstract excerpt
BACKGROUND: Our aim was to study the in vivo viral genetic pathways for resistance to raltegravir, in antiretroviral-experienced patients with virological failure (VF) on raltegravir-containing regimens. METHODS: We set up a prospective study including antiretroviral-experienced patients receiving raltegravir-based regimens. Integrase (IN) genotypic resistance analysis was performed at baseline. IN was also...
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