Article
Preventive and therapeutic effects of tacrolimus in an interleukin-10-deficient mouse model of colitis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] - 1 Nov 2011
Okada Yohei, Maeda Noriaki, Takakura Shoji, Miyata Keiji, Koshiba Masahiro
Abstract excerpt
OBJECTIVE: To investigate the preventive and therapeutic effects of tacrolimus on colonic inflammation in interleukin-10-deficient (IL-10(-/-)) mice, which spontaneously develop T-cell-mediated colitis. METHODS: Tacrolimus or prednisolone, an anti-inflammatory glucocorticoid, was administered to IL-10(-/-) mice with pre- or post-symptomatic colitis. Effects on colonic inflammation were examined by measuring...
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